By Allan I. Basbaum (auth.), T. H. Stanley, M. A. Ashburn (eds.)

Anesthesiology and discomfort Management comprises the edited shows of the thirty ninth Annual Postgraduate direction in Anesthesiology, February 1994. The chapters mirror new information recommendations in the basic framework of `pain examine and easy science', and `clinical issues in ache management'. the aim of the textbook is to function a car to convey a few of the most modern suggestions in anesthesiology to those that didn't attend the convention, inside a little while of the formal presentation. every one bankruptcy is a quick yet sharply targeted glimpse of the present pursuits in anesthesia. This quantity, in addition to prior and destiny volumes, displays the fast and carrying on with evolution of anesthesiology within the past due 20th century.

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How does the expansion of the receptive fields of nociceptive neurons lead to hyperalgesia? One hypothesis (1) is that expanded receptive fields will result in greater overlap of the receptive fields of neurons and, therefore, will lead to a greater number of neurons activated by a stimulus than the number activated by the same stimulus applied in the absence of receptive field expansion. The increase in neuronal activity may ultimately be perceived as more intense pain. It appears that both the observed changes in receptive field size of superficial dorsal horn neurons and the alterations in dynorphin gene expression are closely correlated with the development of behavioral hyperalgesia.

Aromatic Group (Lipophilic) ESTERS Intermediate Chain Amine Group (Hydrophilic) C2Hs PROCAINE H2N ----

Amsterdam, Elsevier, 1991, pp. 263-276 Goelet P, Castellucci VF, Schacher S, Kandel ER: The long and short of long-term memory-a molecular framework. Nature 322:419-422, 1986 Dubner R, Ruda MA: Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci 15:96-103, 1992 Millan MJ, Millan MH, Czlonkowski A, et al: A model of chronic pain in the rat: Response of multiple opioid systems to adjuvantinduced arthritis. J Neurosci 6:899-906, 1986 Millan MJ, Czlonkowski A, Morris B, et al: Inflammation of the hind limb as a model of unilateral, localized pain: Influence on multiple opioid systems in the spinal cord of the rat.

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