By Dennis F. Kohn, Sally K. Wixson, William J. White, G. John Benson

Anesthesia and Analgesia in Laboratory Animals focuses solely at the unique anesthetic, analgesic, and postoperative care specifications linked to experimental surgical procedure. subsidized by way of the yankee university of Laboratory Animal medication, this informative paintings offers the reader with brokers, tools, and methods for anesthesia and analgesia that be sure humane and profitable procedural results.

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1990; Payne, 1971). Gas chromatography is a technique used to measure volatile anesthetics in both liquids or gases and allows identification and measurement of very low concentrations of gas mixtures.

40 I. I N T R O D U C T I O N The anesthetic properties of ether and chloroform were discovered in the 1840s and remained the only significant inhaled anesthetics until 1925 (Reynolds, 1981). Diethyl ether became the first routinely used anesthetic for research animal anesthesia. Researchers recognized that ether produced a stable anesthetic state that could be predictably reversed. The wide margin ANESTHESIA AND ANALGESIA IN LABORATORY ANIMALS Copyright 9 1997 by Academic Press.

4 aData from Eger (1974) and Jones (1990). Tissue/blood partition coefficients also influence the anesthetic uptake. However, tissue solubility is even more important during elimination of the inhaled anesthetics. Anesthetics with high lipid solubilities will accumulate in fat tissue during anesthesia. On recovery the anesthetic will leave the fat and slow the animal's return to consciousness (Table IV). Lipid solubility and potency seemingly have a reciprocal relationship which has led to the theory that the mode of action of gas anesthetics is related to a relative constant number of anesthetic molecules dissolved in a hydrophobic phase [the "Unitary Theory" (Kaufman, 1977)].

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